New Research: MXenes as Efficient Thermal Catalysts for Hydroamination

MXenes have gained attention for their electrocatalytic and energy storage capabilities, but their role in thermal catalysis remains largely unexplored. Our latest study, published on January 20, 2025, demonstrates the exceptional catalytic activity of Ti₃C₂ MXene for the regioselective anti-Markovnikov hydroamination of terminal alkynes—an essential transformation in organic synthesis.

🔹 Unparalleled Selectivity & Efficiency
Unlike traditional solid catalysts, Ti₃C₂ MXene exhibits near-complete selectivity for the anti-Markovnikov product, efficiently catalyzing hydroamination for both aliphatic and aromatic amines. Additionally, it facilitates intramolecular hydroamination, leading to the formation of indole heterocycles.

🔹 Remarkable Turnover Frequencies
Ti₃C₂ delivers high turnover frequencies (TOF) of up to 350 h⁻¹, making it one of the most effective heterogeneous hydroamination catalysts studied to date.

🔹 A Step Toward Broader Applications
By leveraging MXenes’ compositional and structural versatility, this work opens new opportunities for their use in organic synthesis beyond electrocatalysis.

📖 Read the full study here:  https://pubs.acs.org/doi/abs/10.1021/jacs.4c13481

#Catalysis #MXenes #Hydroamination #OrganicChemistry #MaterialsScience